Neuropathic pain, or nerve pain, results from disease, malfunction, or injury of the central nervous system (the brain and spinal cord) or peripheral nervous system (everything else). Nerve pain is most often described as having the following characteristics: prickling (pins and needles), persistent tingling and/or numbness, and burning sensations without a source of heat present.

Neuropathic pain tends to be chronic and more difficult to treat.